Treatment for venereal diseases



WILLIAM E. CRAIG, OF JOPLIN, MISSOURI, ASSIGNOR, BY CRAIG CHEMICAL CORPORATION, OF CLEVELAND, OHIO,

MESNE ASSIGNMENTS, To A CORPORATION or DELA- Patented Feb. 28, 1922.

WARE.

TREATMENT FOR VENEREAL DISEASES.

1,408,170. Specification of Letters Patent.

No Drawing.

1 '0 all whom it may concern:

Be it known that I, IVILLIAM E. CRAIG, a citizen of the United States, residing at Jo lin, in the county of Jasper and State of issouri, have invented certain new and useful Improvements in Treatments for Venereal Diseases; and I do hereby declare the following to be a full, clear, and exact description of the invention, such as will enable others skilled in the art to which it appertains to make and use the same.

This invention is characterized by being not only a treatment of but a proven cure for syphilis in any stage, the more virulent warned against the use of acids, but an accidental or slight use of acid foods usually will not be found injurious.

F or mild or earlier stages of the disease, I administer as one dose for an adult two thirty-seconds of a grain of opium; thirtytwo thirty-seconds of a grain of blue mass; ten thirty-seconds of a grain of sulphate of quinine, and ten thirty-seconds of a gram of licorice. This dose is given three times per day. For more virulent or advanced.

stages the same materials and number of doses are administered but strengthened. by employing four thirty-seconds of a grain of opium; forty-eight thirty-seconds grains of blue mass; sixteen thirty-seconds of a grain of sulphate of quinine, and twenty thirtyseconds of a grain. of licorice. For children, the dose should be reduced proportionally to the age within the discretion of the physician, and in instances where it is difficult to get a child to take" the medicine in the form of a solid, the physician may crush the tablet, or such fraction thereof as he determines should be usedas a dose and give it in Water. Tablets may be specially made softer'or more friable to facilitate this op eration.

Application filed December 5, 1918. Serial No. 265,356.

I am able to administer this remedy as a continuous treatment Without cessation up to the point of complete cure; and in all. of the cases which I have treated I have not had a single instance of mercuric poisoning.

F or convenience of reference, I have called. the lighter treatment N o. '1, and the stronger treatment No. 2. Presented as formuilze these two treatments are preferably prepared as follows Pulverized opium, grains II. Iulvis pill hydrarge, grains XXXII. Quinine sulphate, grains X.

Licorice powder, grains X.

Extract malt, Qs. mass.

M. ft. tablets XXXII.

Signature: one three times daily.

The abbreviation Qs, as is Well known to the profession, is employed to signify quantity sufficient. 7

Pulverized opium, grains IV.

Pulvis pill hydrarge, grains XLVIII.

Quinine sulphate, grains XVI.

Licorice powder, grains XX.

Extract malt, Qs. mass.

M. ft. tablets, XXXII.

Signature: One three times daily.

It should be understood that pulvis pill iydrarge (blue mass) is preferably. employed because of its accessibility, but, of course, itis to be understood that the same or similar results may be obtained by the.

utilization of mercury in the same or sub stantially the same quantitieseven if otherwise prepared and employed with other diluent, so long as not presented in a form either injurious to the patient or failing to have the requisite therapeutical action.

It will also be noted that in each of the formulae above given there is included sufficient malt to make a pill mass, and the malt serves as a binder, facilitating the pr0- duction of tablets. Any appropriate substitutes maybe utilized for this binder.

The actual steps of the operation of preparing the remedy consistent with the two above-quoted formula are the same in both cases and may be stated as'follows:

First Weigh out the quinine, then the amount of ulverized opium and thoroughly triturate t em; then add the pulvis pill hydrarge, and then thoroughly triturate again; then add the licorice powder and again thoroughly triturate until all ingredients are thoroughly mixed; then add sullicient extract of malt to make a pill mass. After this process is completed, the compound is put into a bake oven and baked until it is thoroughly dried suiiiciently to be converted into a powder. This powder is then run through a sieve and is then ready for the tablet machine.

The bowels should be caused to move at least once a day during treatment, and, it necessary, the patient should take a laxative to effect this result and to avoid any accumulation of mercury, and at the same time prevent touching up of the gums or salivation. Also the physician will understand that in the interest of sanitationand for the comfort of the patient, a palliative treatment for any local irritation should be employed to avoid further inpregnation or irritation, as by the cleansing of a sore or sores and touching it or them with nitrate of silver or other germicidal agent.

The continuation of thetreatment. depends largely on the improvement and the idiosyncrasy of the patien and the length of time that has elapsed sincefthe initial lesion oi the disease. An ordinary case will show marked improvement in two or three weeks, but the reme'dy'should be continued from three, six to twelve months. The length of treatmentis governed largely by the results as shown by the blood tests.

While I am able to demonstrate the effectiveness of the cure thus described, and have already accomplisheda number of perfect.

cures in the testing of the remedy, I do not Wish to be limited to any particular action of any ingredient or mixture or compound of ingredients named. So far as I have been able to ascertain, the mercury acts as a germicidal cholagogue, and the opium tends to retard the peristalsis of the intestines and also as a direct curative agent on lesions. The opium also serves to avoid irritation and pain which might otherwise result from the mercury, and at the same time it lessens the rapidity of the action of the mercury, so as to afford a greater opportunity for absorption. The mercury acts directly to destroy the spirochaeta audits continuous use to the point of complete cure is rendered possible by the utilization of the other agents named therewith. The quinine serves to stimulate the secretions and promote absorption of the mercury, and also increases the tone of the bowels; through its tonic effect. The quinine also has an antitoxic effect. It is, of: course, understood that the greater the absorption of mercury the shorterthe life of the disease and the brie'ler the time required for treatment and cure. The licorice powder is employed par application Serial No. 26453 filed Novem ber 29, 1918, and isfiled tomoreaccurately and fully disclose the preferred embodiment of myinvention, since in the former application through a misreading 01? my formulae by counsel the doses were indicated as a little stronger than preterredby me. Such stronger doses would accomplish the desired results but there might be aslight liability toward irritation with some patients which is entirely avoided. by the lighter doses herein indicated.

What I claim is l. A remedy for internal use for venereal diseases comprising a germicidal cholagogue',

an ingredient adapted to serve as a soothing agent, and an ingredient adapted to serve as a stimulant, the said several constituents being in substantially the quantity and hearing that relative proportion toeachother fixed by the limits of the therapeutical action required substantially as described.

2. A remedy toriinternal use for venereal diseases comprising mercury, an ingredient adapted to serve as a soothing agent, and an ingredientadapted to serve as a stimulant, the said several constituents being in substantially the quantity and bearing that relative proportion to each other fixed by the limits of the therapeutical action re quired substantially as described.

8. A. remedy for internal use for venereal diseases comprising mercury, an ingredient adapted to serve as a stimulant, an ingredient adapted to serve as a soothing'agent, and an ingredient adapted to serve to prevent nausea, the said several constituents being in substantially the quantity and bear ing that relative proportion to each other fixed by the limits of the therapeutical-action required substantially as described.

4:. A remedy for internal useior venereal diseasesjcomprising mercury, an ingredient. adapted to serve as anagent for repressing peristalsis, and an ingredient adapted to serve as a stimulant, the said several constituents being in substantially the quantity and bearing that relative proportion to each other fixed by the limits of the therapeutical action required substantially as described.

A remedy for internal use for venereal diseases comprising mercury, an ingredient.

adapted to serve as an agent for repressing peristalsis, and quinine, the said several constituents being in substantially the quantity and bearing that relative proportion toeach other fixed by the limits of the therapeutical actionrequired substantially as described.

6. A remedy for internal use for venereal diseases comprising mercury, an ingredient adapted to serve as a stimulant, and opium, the said several constituents being in substantially the quantity andbearing that relative proportion to each other fixed by the limits of the therapeutical action required substantially as described.

7 A remedy for internal use for venereal diseases comprising mercury, an ingredient adapted to serve as a stimulant, an ingredient adapted to serve as a soothing agent, and licorice, the said several constituents being in substantially the quantity and bearing that relative proportion to each other fixed by the limits of the therapeutical action required substantially as described.

8. A remedy for internal use for venereal diseases comprising mercury, opium and quinine, the said several constituents being in substantially the quantity and bearing that relative proportion to each other fixed by the limits of the therapeutical action required substantially as described.

9. A remedy for internal use for venereal diseases comprising pants the substantial equivalent in therapeutical action of and proportioned. to be equal substantially to that percentage represented by two thirty seconds of a grain of opium, thirty-two thirty-seconds of a grain of pulvis pill hydrarge, and ten thirty-seconds of a grain of sulphate of quinine.

10. A remedy for internal use for venereal diseases comprising parts the substantial equivalent in therapeutical action of and proportioned to be equal substantially to that percentage represented by four thirtyseconds of a grain of opium, forty-eight thirty-seconds grains of pulvis pill hydrarge, and sixteen thirty-seconds of a grain of sulphate of quinine.

11. A remedy for internal use for venereal diseases comprising mercury, opium, quinine, and licorice, the said several constituents be ing in substantially the quantity and bearing that relative proportion to each other fixed by the limits of the therapeutical ac tion required substantially as described.

1 A remedy for internal use for venereal diseases comprising tablets formed of parts the substantial equivalent in therapeutical action of andproportioned to be equal sub stantially to that percentage represented by thirty-two tablets made from a'substance resulting from the intermixture of the following parts: pulverized opium, grains II; pulvis pill hydrarge, grains XXXII; quinine sulphate, grains X; licorice powder, grains X; extract malt, Qs. mass.

13. A remedy for internal use for venereal diseases comprising tablets formed of parts the substantial equivalent in therapeutical action of and proportioned to be equal substantially to that percentage represented by thirty-two tablets made from a substance resulting from the intermixture of the following part-s: pulverized opium, grains IV; pulvis pill hydrarge, grains XLVIII; quinine sulphate, grains XVI; licorice powder, grains XX; extract malt Qs. mass.

In testimony whereof I aflix my signature in presence of a witness.

WILLIAM E. CRAIG. lVitness:

C. H. FnsLmR. 

